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Human Tissue inhibitors of metalloproteinase 4 (TIMP4) ELISA Kit

Human Tissue inhibitors of metalloproteinase 4 (TIMP4) ELISA Kit

SKU: KTE60324
399,00€Price
This Human Tissue inhibitors of metalloproteinase 4 (TIMP4) ELISA Kit employs a two-site sandwich ELISA to quantitate TIMP4.
Leco et al. (1997) cloned cDNAs encoding mouse Timp4. The predicted Timp4 protein contains the hallmarks of TIMP proteins, including 12 conserved cysteine residues and 2 short conserved sequence motifs. Northern blot analysis of adult mouse tissues detected Timp4 expression in brain, heart, ovary, and skeletal muscle. Olson et al., 1998 determined that the TIMP4 gene contains 5 exons that span 6 kb of genomic DNA. They demonstrated a high degree of conservation of gene structure in the TIMP family. By FISH, Olson et al., 1998 mapped the TIMP4 gene to chromosome 3p25. By interspecific backcross analysis, they mapped the mouse Timp4 gene to chromosome 6 in a region of syntenic homology with human chromosome 3.
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