Human TAR DNA-binding protein 43 (TARDBP/TDP43) ELISA Kit

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. TAR DNA-binding protein 43 (TARDBP/TDP43) is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, TARDBP/TDP43 regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.